FIELD: medicine. SUBSTANCE: described are new 12,13-epoxytilosine derivatives of formula I: 
wherein R is 0; R1 is CHO or CH(OCH3)2, R2 is H or micarosyl and ---- denotes single bond; or wherein R is NOH, R1 is CHO or CH(OCH3)2; R2 is H or micarosyl and ---- denotes single or double bond; or compounds of formula II 
wherein R is H or micarosyl. Compounds show antimicrobial effect. Also described are methods of preparation thereof. EFFECT: improved properties of the title compounds. 18 cl
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Year |
Author |
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| DERIVATIVES OF 10,11,12,13-TETRAHYDRODESMYCOSINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS WITH ORGANIC OR INORGANIC ACIDS SHOWING ANTIBACTERIAL ACTIVITY, A METHOD OF SYNTHESIS OF DERIVATIVES OF 10,11,12,13-TETRAHYDRODESMYCOSINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
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1994 |
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| EPOXY-AZETHIDINONES |
1998 |
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