FIELD: organic chemistry, medicine, endocrinology. SUBSTANCE: invention relates to novel inositol glycans with insulin-like effect of the formula (I): A-Z-R where A means H-P(O)(OH)-, H-P(S)(OH)-, HO-P(S)(OH)-, S(O)2(OR1)- or NH2-C(O)- where R12 means hydrogen atom or (C1-C4)-alkyl; Z means 2-6 sugar residues among the group mannose, glucose, gluconic acid, galactonic acid, mannonic acid, glucosamine, fructose or galactose or 2-6 sugar residues among the group indicated for Z substituted mono-sixfold with methyl, mannose, glucosamine, dimannose or mannose-glucosamine independently each of other and glycoside bond of both sugars of mannose and glycosamine is located between C-atoms 1-3, 1-2 or 1-6 of both sugars; R means inositol, inositol phosphate, inositol thiophosphate, inositol cyclothiophosphate or inositol cyclophosphate. Invention relates to also method of synthesis of indicated compounds, pharmaceutical composition based on thereof and method of pharmaceutical composition preparing. Invention can be used for treatment of patients with diabetes mellitus. EFFECT: new compounds indicated above, improved method of synthesis and pharmaceutical composition preparing, valuable antidiabetic properties. 9 cl, 2 tbl, 3 ex
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Authors
Dates
2002-01-27—Published
1997-11-27—Filed