HEPTAPEPTIDE OXYTOCIN ANALOGS Russian patent published in 2002 - IPC

FIELD: biochemical methods. SUBSTANCE: invention relates to heptapeptide oxytocin analogs of general formula S-Z, wherein S denotes heptapeptide moiety and Z group -NR-CH(Q)-CH₂OH,, in which Q is group (CH₂)-NH-A n is integer from 1 to 6, A is hydrogen, and R denotes methyl or ethyl group, manifesting activity of oxytocin antagonists. Proposed compounds are characterized by improved stability if aqueous media simultaneously retaining their selectivity and therapeutic efficiency. Method of preparing heptapeptide oxytocin analogs, pharmaceutical composition containing thereof, method of preparing the composition, and method of treating premature birth are also provided. EFFECT: increased choice of biologically active substances. 29 cl, 6 tbl, 11 ex