FIELD: medicine; pharmacology.
SUBSTANCE: invention refers to pharmacology. Present invention relates to cyclic analogue of appelin of general formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14 containing lantionine bridge of Ala-S-Ala structure or methyl-lithium bridge structure Abu-S-Ala or Ala-S-Abu, and where the values X1-X14 and the size of the lantionine and methyl-l-thionine bridge are defined in the claim.
EFFECT: novel apeline analogues and therapeutic application thereof are disclosed.
19 cl, 8 tbl, 8 ex
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