SYNTHETIC ANALOGS OF IL-10 Russian patent published in 2002 - IPC

FIELD: biochemistry, proteins, cytokines. SUBSTANCE: invention relates to polypeptides including the following sequence: Thr-X₄-Lys-X₅-Arg-X₆ where X₄ and X₅ are taken independently among group comprising of Met, Ile, Leu and Val and X₆ is taken among group comprising of Asn, Asp, Gln and Glu. Compounds show IL-10-like activity and can be used as agonists or antagonists of IL-10 (interleukin-10). Invention describes also pharmaceutical composition comprising indicated polypeptide and method of its preparing. EFFECT: improved method of preparing, valuable properties. 23 cl, 14 dwg, 5 tbl, 17 ex