1-(4-NITROPHENYL)-4-N-X-AMINOPYRROLIDONES-2 SHOWING GROWTH-REGULATING AND ANTISTRESSING ACTIVITY AND METHOD OF THEIR SYNTHESIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel chemical biologically active compounds of order 1-(4-nitro-phenyl)-4-N-X-aminopyrrolidones of the general formula: where X means (II); -NH-C₄H₉ (III); -NH₂ (IV); -NH-C₂H₅ (V) showing the growth-regulating and antistressing activity and to method of their synthesis. Compounds of the formulas (II), (III) and (V) are synthesized by heating a mixture of 0.5 g (0.025 mole) of 1-(4-nitrophenyl)-pyrroline-2-one dissolved in 20 ml of dimethylformamide and 0.075 mole of a corresponding amine (cyclohexylamine, n-butylamine, ethylamine) and its stirring under thermostatic control at 90 ± 2 C for 2 h followed by reaction mixture cooling. Compound (IV) is synthesized by heating solution of 0.5 g (0.025 mole) of 1-(4-nitro-phenyl)-pyrroline-2-one in 20 ml of dimethylformamide up to 90 ± 2 C for 2 h at stirring by passing gaseous ammonia formed at heating of 60 ml of 20% ammonia solution followed by cooling. Preparations (V) and (III) show the highest efficiency for improvement of sowing quality of winter wheat seeds of the sort Pobeda-50. Preparations (III) and (II) show the most antistressing activity. EFFECT: improved method of synthesis, valuable properties of compounds. 2 cl, 2 tbl, 5 ex