METHOD OF PREPARING MONOCLONAL ANTIBODY RAISED AGAINST T-CELLS SURFACE ANTIGEN, MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION AND DIAGNOSTIC REAGENT Russian patent published in 2003 - IPC

Abstract RU 2196178 C2

FIELD: medicine, immunology. SUBSTANCE: monoclonal antibody is produced by hybridomas obtained by using material containing antigen of cellular surface taken among group of whole T-cells or their membrane fraction. Monoclonal antibody is specific to clone-typical structure of T-cellular receptor and T- cellular receptor is associated with autoimmune sickness, in part, rheumatic arthritis. Pharmaceutical composition used for treatment of rheumatic arthritis and reagent is used for diagnosis of autoimmune sickness are prepared on the base of monoclonal antibody. Invention allows to prepare antibodies raised against rare and/or unstable antigens and excluding screening of large amounts of hybridoma vectors. Invention can be used for preparing antibodies and diagnosis of autoimmune sickness and for treatment of rheumatic arthritis. EFFECT: improved method of preparing, enhanced effectiveness of treatment. 5 cl, 7 dwg, 3 tbl

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RU 2 196 178 C2

Authors

Stenbakkers Petrus Gerardus Antonius

Dates

2003-01-10—Published

1997-12-05—Filed