FIELD: organic chemistry, chemical technology, medicine, gastroeneterology, pharmacy. SUBSTANCE: invention relates to the improved method of synthesis of omeprazole that is the first medicinal agent of group of drugs used for control of gastric acid secretion. Invention describes method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl-1H-benzimidazole (omeprazole) of the formula: 
. Method involves interaction of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)-methyl] thio] benzimidazole with 3-chloroperoxybenzoic acid and indicated interaction is carried out in ethyl acetate medium at temperature between -10 C and 5 C. Synthesized product is purified by its dissolving in methylamine aqueous solution, precipitated by addition of hydrochloric acid and compound is isolated in pure form. Invention provides the development of the improved method of synthesis of omeprazole of high purity degree. EFFECT: improved method of synthesis. 2 ex
| Title |
Year |
Author |
Number |
| METHOD OF ISOLATION OF CLAVULANIC ACID |
1995 |
|
RU2206613C2 |
| METHOD OF PRODUCING 2-//-5(DIMETHYLAMINO)-METHYL-2-FURANYL/-METHYL/-THIO/-ETHANAMINE |
0 |
- Alenka Khribar-Kikeli
- Yanko Zhmitek
- Iolanda Lakh
|
SU1187719A3 |
| METHOD FOR PRODUCTION OF 3-ETHYL-5-METHYL-(±)2/(2-AMINOETHOXY)-METHYL-4-(2-CHLOROPHENYL)-1,4- -DIHYDRO-6-METHYL-3,5-PYRIDINE CARBOXYLATE MONOBENZOATE AND INTERMEDIATE FOR THEM |
1993 |
- Borut Furlan[Si]
- Anton Chopar[Si]
- Alenka Jerikha[Si]
|
RU2105759C1 |
| METHOD OF PRODUCING 5-METHYL 3B-(N-BENZYL-N METHYLAMINO)-ETHYL ESTER OF 2,6-DIMETHYL-4-(3Ъ-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOLIC ACID OR ITS CHLORIDE |
0 |
- Lyubo Antonchich
- Iztok Yazbets
- Darko Kotsan
- Ivana Krivets
|
SU1493104A3 |
| PROCESS FOR PREPARING DISODIUM SALT OF ([2-(2-AMINOTHIAZOL- -4-YL)-2-SYN-METHOXYIMINO]ACETAMIDO)-3-([2,5-DIHYDRO-6- -HYDROXY-2-METHYL-5-OXO-AS-TRIAZIN-3-YL)THIO]METHYL)-3- CEPHEM-4-CARBOXYLIX ACID AND DISODIUM SALT OF OF 7-AMINO- -3-[(2,5-DIHYDRO-6-HYDROXY-2-METHYL-OXO-AS-TRIAZIN-3-YL-THIO] METHYL)-3-CEPHEM-4-CARBOXYLIC ACID |
1993 |
- Natasha Khafner-Milach[Si]
- Igor' Langof[Si]
- Boris Rus'Jakovski[Si]
- Sandi Borizhek[Si]
- Dar'Ja Jereb[Si]
|
RU2081120C1 |
| THREE-PHASE PHARMACEUTICAL FORM WITH CONSTANT AND CONTROLLED RELEASE OF AMORPHOUS ACTIVE INGREDIENT FOR SINGLE DAILY ADMINISTRATION |
1996 |
- Janez Kerch
- Ljubomira Barbara Rebich
- Bojan Kofler
|
RU2161956C2 |
| METHOD OF PREPARING N-SUBSTITUTED ESTERS OF 9,10-DIHYDROLYSERGIC ACID |
0 |
|
SU784775A3 |
| METHOD OF PRODUCING N-2-//5-(DIMETHYLAMINO)-METHYL-2-FURANYL/-METHYL/-THIOETHYL-N-METHYL-2-NITRO-1,1-ETHENDIAMINE OR ITS PHYSIOLOGICALLY BEARABLE ACID-ADDITIVE SALTS |
0 |
- Alenka Khribar-Kikeli
- Yanko Zhmitek
- Jolanda Lakh
|
SU1194277A3 |
| METHOD OF OBTAINING DIMETHYL-(N-CYANIMIDO)CARBONATE |
0 |
- Brane Jenko
- Frants Lipovshek
- Zdenka Lindich
- Frants Jeraj
|
SU1165230A3 |
| METHOD OF PRODUCING 5-METHYL 3 BETA-(N-BENZYL-N-METHYLAMINO)-ETHYL ETHER 2,6-DIMETHYL-4-(3 PRIME-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID OR HYDROCHLORIDE THEREOF |
0 |
- Lyubo Antonchich
- Iztok Yazbets
- Darko Kotsan
- Ivana Krivets
|
SU1419516A3 |
