NOVEL CRYSTALLINE MODIFICATION OF 5-FLUORO-1-(TETRAHYDRO-2-FURYL)-URACIL AND COMPLEX COMPOUNDS BASED ON THEREOF EXHIBITING ANTITUMOR EFFECT Russian patent published in 2003 - IPC

Abstract RU 2198171 C2

FIELD: organic chemistry, heterocyclic compounds, medicine, oncology. SUBSTANCE: invention relates to novel crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl)-uracil and also to complex compounds of this form with 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine or licorice roots extract (Radices Glycyrrhizae). By its indices this form differs from the early known modification of this compound and shows the enhanced antitumor activity and used in medicine. New form shows the enhanced stability and it can form stable molecular complexes with biologically active compounds that elicit similar properties. EFFECT: enhanced activity and stability of synthesized compounds. 10 cl, 14 dwg, 2 tbl, 4 ex

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RU 2 198 171 C2

Authors

Leonidov N.B.

Dates

2003-02-10Published

1998-10-12Filed