AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where A means optionally substituted phenyl under condition that groups -CH(R³)N(R²)M-R¹ and -OD are in 1,2-position with respect to with each other in carbon ring atoms and carbon ring atom locating in ortho-position to -OD-binding group (therefore, at 3-position with respect to -CHR³NR²-binding group) is unsubstituted; B means pyridyl or pyridazinyl; R¹ is located in ring B in 1,4-position with respect to -CHR³NR²- binding group and presented as determined in claim 1 of the invention claim; R² means C_1-6-alkyl; R³ means hydrogen atom; D means hydrogen atom, optionally substituted 5-7-membered carbocyclic ring containing one double bond or D means group of the formula (CH₂)_nCH(R⁴)C(R⁵)=C(R⁶)R⁷ where R⁴ means hydrogen atom, methyl or ethyl group; R⁵ means hydrogen atom, methyl group, bromine, chlorine or fluorine atom; R⁶ means hydrogen atom, C_1-4-alkyl; R⁷ means hydrogen atom, C_1-4-alkyl, bromine, chlorine or fluorine atom; n = 0 or 1. Invention relates also to their pharmaceutically acceptable salts or esters hydrolyzed in vivo. Compounds are antagonists of effect of prostaglandin E-type enhancing pain. Also, invention relates to pharmaceutical composition used for pain relief based on the above described compounds and to method of pain relief using the above described compounds. Also, invention proposes method of synthesis of compounds of the formula (I) based on the above described compounds and their pharmaceutically acceptable salts or esters hydrolyzed in vivo and intermediate compounds synthesized in the process of their synthesis. EFFECT: improved methods of synthesis and preparing, valuable medicinal properties. 13 cl, 6 tbl, 67 ex