NEW TETRAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS Russian patent published in 2023 - IPC C07D401/06 C07D403/06 C07D405/06 C07D249/06 C07D257/04 A61K31/06 A61K31/4192 A61K31/4196 A61K31/506 A61K31/4439 A61K31/497 A61K31/501 A61P31/06 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacteria such as tuberculosis. The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is CH or N; n is 0, 1 or 2; R¹ is methyl, ethyl, cyanomethyl, C-linked acetamido, methyl acetate, 2-hydroxyethyl, 2-hydroxy-1-propyl, 1,3-dihydroxy-2-propyl, or 1,2-dihydroxy-3-propyl; R² is independently selected from halogen, C_1-2 alkyl, or C_1-2 alkoxy; R³ is phenyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl, where each of these groups may be optionally substituted with one or two substituents selected from halogen, cyano, C_1-2 alkyl optionally substituted with no more than three fluorine atoms, and C_1-2 alkoxy optionally substituted with no more than three fluorine atoms, where the substituents may be the same or different; or R³ is cyclohexyl which may be optionally substituted with one or two fluorine or chlorine atoms, where each substituent may be attached to the same carbon atom and each substituent may be the same or different; or R³ is tetrahydropyran; and R⁴ is H or methyl. The invention also relates to a pharmaceutical composition based on the said compound.

EFFECT: new compounds and a pharmaceutical composition based on them can be used in medicine for the treatment of mycobacterial infections or for the treatment of diseases caused by mycobacteria, such as tuberculosis.

19 cl, 6 tbl, 115 ex