FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel bicyclic derivatives of pyrimidine. Invention describes bicyclic derivatives of pyrimidine of the general formulas (I): 
and (II): 
where radicals A, Z1,Z2,R1,R2,R3,R4,R5,R6,R7,R8,R9,R10 are given in claim 1 of the invention claim. Also, invention describes pharmaceutical composition based on compounds of the formula (I) and (II) that exhibits activity with respect to human factor Xa. Invention provides synthesis of novel compounds with useful biological properties. EFFECT: valuable medicinal properties of compounds. 12 cl, 8 ex
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