SUBSTITUTED 6- AND 7-AMINOTETRAHYDROISOQUINOLINE CARBOXYLIC ACIDS Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention describes substituted 6- and 7-aminotetrahydroisoquinoline carboxylic acids of the formula (I) and/or their R- isomeric form, and/or their physiologically tolerated salts wherein R¹ is phenyl monosubstituted with (C₁-C₆)-alkyl-O-, halogen atom; -OR¹⁴ wherein R¹⁴ is (C₁-C₆)-alkyl; R² is HO(H)N- or R⁷-O- wherein R⁷ is hydrogen atom or (C₁-C₆)-alkyl; R³ and R⁴ are similar or different and mean hydrogen atom, R⁸-(CO)-, wherein R⁸ is R⁷-O-C(O)-(CH₂)_n; R⁷-N(H)-(R⁹)-C(H)-wherein R⁹ means specific radical of proteinogenic 2-amino acid alanine, R¹⁰-O-C(O)-N(H)-(R⁹)-C(H)-wherein R¹⁰ is (C₁-C₆)-alkyl or benzyl; R³ and R⁴ in common with nitrogen atom form nitro radical; A is covalent bond; B is (CH₂)_m, wherein m = 0; x is CH=CH-. Compounds are inhibitors of matrix metallo- proteinases. EFFECT: valuable biochemical properties of compounds. 2 cl, 1 dwg, 2 tbl, 11 ex