DERIVATIVES OF PHOSPHINIC AND PHOSPHONIC ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2004 - IPC

FIELD: organophosphorus compounds, biochemistry, pharmacy. SUBSTANCE: invention relates to derivatives of phosphinic and phosphonic acids of the formula (I): wherein R¹ means unsubstituted or substituted phenyl, -O-((C₁-C₆)-alkyl); R² means hydrogen atom; R and R³ mean hydrogen atom, alkyl, unsubstituted or substituted phenyl, groups COOH or (CH₂)₂-CH(COOH)-NH-SO₂-C₆H₄-C₆H₄-Cl(n); t means a whole number 1-4; A means covalent bond; Y means group -CH=CH-; B means group -(CH₂)₀- wherein o = 0, 1, 2 or 3; Y¹ and Y² mean -OH, -(C₁-C₄)-alkyl, -O-(C₁-C₄)-alkyl, and/or their stereoisomeric forms and/or physiologically acceptable salts. Compounds of the formula (I) shows activity with regard to metalloproteinase and can be used in medicine. EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds. 7 cl, 3 tbl, 6 ex