FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to the development of the improved method for preparing 2,7-bis-[2- (diethylamino)ethoxyfluorenone-9 dihydrochloride. Method involves sulfonation reaction of fluorine to fluorine 2,7-disulfoacid disodium salt, its alkaline melting and the following cyclization with zinc chloride, alkylation with 2-diethylaminoethylchloride hydrochloride. Sulfonation reaction is carried out with sulfuric acid with its density 1.83-1.84 g/sm3 and alkaline melting reaction is carried out in wetting substrate with ammonia water and using mixture sodium nitrate and potassium nitrate taken in the ratio each to other = 5:1. EFFECT: improved preparing method. 2 cl
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Authors
Dates
2003-12-10—Published
1999-03-17—Filed