METHOD FOR PREPARING 2,7-BIS-[2-(DIETHYLAMINO)- ETHOXY]FLUORENONE-9 DIHYDROCHLORIDE AS ANTIVIRAL AND IMMUNOMODULATION PREPARATION "AMIXINUM" Russian patent published in 2003 - IPC

Abstract RU 2218327 C2

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to the development of the improved method for preparing 2,7-bis-[2- (diethylamino)ethoxyfluorenone-9 dihydrochloride. Method involves sulfonation reaction of fluorine to fluorine 2,7-disulfoacid disodium salt, its alkaline melting and the following cyclization with zinc chloride, alkylation with 2-diethylaminoethylchloride hydrochloride. Sulfonation reaction is carried out with sulfuric acid with its density 1.83-1.84 g/sm3 and alkaline melting reaction is carried out in wetting substrate with ammonia water and using mixture sodium nitrate and potassium nitrate taken in the ratio each to other = 5:1. EFFECT: improved preparing method. 2 cl

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RU 2 218 327 C2

Authors

Poplavskij A.N.

Djumaev K.M.

Kozlov V.A.

Ryzhichkov A.D.

Dates

2003-12-10Published

1999-03-17Filed