METHOD FOR PREPARING INTERMEDIATE COMPOUNDS Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to new methods for preparing compounds of the formula (I): wherein one group among R¹ and R² means cyclopropyl and another means phenyl substituted with two or three groups that can be similar or different and taken among halogen atom, nitro-, cyano-group, -(CR⁴R⁵)S(O)_pR⁶, -S(O)_pR⁶, C_1-6-alkoxy-group, C_1-4-haloalkoxy-group, C_1-4-alkyl, C_1-4- haloalkyl and -SF₅; wherein p = 0, 1 or 2; R⁴ and R⁵ mean hydrogen atom independently or C_1-4-alkyl; R⁶ means C_1-4-alkyl. Method involves hydrolysis and decarboxylation of compound of the formula (II): wherein R¹ and R² are given above and R³ means C_1-4-alkyl in the presence of water. Compound of the formula (II) is prepared by acylation of compound of the formula (III): wherein R¹ and R³ are given above with compound of the formula (IV): R²C(= O)X (IV) wherein R² is given above; X means removing group. Method is carried out in the presence of magnesium halide and a base. Compound of the formula (III) wherein R′ means cyclopropyl is prepared by interaction of compound of the formula (V) wherein R¹ means cyclopropyl and Y is substituted or unsubstituted imidazole-1-yl ring with compound of the formula (VI): wherein R³ is given above via decarboxylation of compound of the formula (VII): wherein R¹ means cyclopropyl and R³ is given above. EFFECT: improved preparing methods. 19 cl, 9 ex