FIELD: medicine, biotechnology, genetic engineering and therapy.
SUBSTANCE: invention proposes a method for preparing recombinant mammalian adenovirus and recombinant mammalian adenovirus. Method for preparing recombinant adenovirus involves insertion of heterologous DNA sequence comprising at least one therapeutic gene into adenovirus and mammalian adenovirus is used as adenovirus. Recombinant mammalian adenovirus comprises heterologous DNA sequence comprising at least one therapeutic gene that is inserted into adenovirus genome taken among the group of strains Manhattan or A 26/61 (ATCC VR-800) of adenovirus CAV-2 and strains ATCC VR-1343 and ATCC VR-1340 of ovine adenovirus. The prepared recombinant adenovirus is used for carrying out the genetic therapy in humans.
EFFECT: valuable medicinal properties of vectors.
10 cl, 5 dwg, 5 ex
