DERIVATIVES OF NAPHTHYRIDINE AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of naphthyridine of the general formula (I) or their pharmaceutically acceptable salts:

wherein: R¹: -R⁰ or -lower alkylene-cycloalkyl; R⁰: -lower alkyl; R²: -R⁰, -halogen atom, -lower alkylene-OH, -S-R^o, -NHR⁰ or -CH=N-OR⁹ that can be similar or distinct of one another; R³ and R⁴: -H; R⁹: -H; R⁵: cyclohexyl, thienyl or phenyl that can be substituted with group taken among lower alkyl and halogen atom; R⁶: -OH, -OR⁷, -COOH, -CONH₂, -CON(R⁷)₂, -O-COR⁷, -O-COOR⁷, -COR⁷, -NH₂, -N(R⁷)₂, -N(R⁷)COR⁷, -N(R⁷)SO₂R⁷, -C(NH)NH₂, -NHC(NH)NH₂ or group of the formula: -Y-R⁸; R⁷: lower alkyl that can be substituted with group -CO₂R^0; R⁸: phenyl that can be substituted with group taken among R¹⁰, or heterocyclic group taken among morpholinyl, tetrazolyl, imidazolyl, pyridyl, piperidyl, thiazolyl, piperazyl, pyrrolidyl or imidazo[1,2-a]pyridyl that can be substituted with group taken among R¹⁰; R¹⁰: -halogen atom, -CO₂H, -NH₂ or -COR⁰, or group described as R⁷; Y: a bind or -CO-; X: a bind or lower alkylene. These compounds can be used as prophylactic or curative agents in treatment of respiratory diseases associated with inhibition of activity of phosphodiesterase-IV.

EFFECT: valuable medicinal properties of compounds and composition.

7 cl, 6 tbl, 57 ex