OXAZOLIDINONE-QUINOLONE-HYBRID ANTIBIOTICS Russian patent published in 2009 - IPC C07D471/04 C07D413/10 C07D413/12 C07D413/14 C07D498/06 C07F9/553 C07F9/59 A61K31/422 A61K31/435 A61K31/4375 A61K31/4353 A61P31/00 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to formula (I), compounds, , their pharmacologically acceptable salt, solvate and hydrate, where A is an alkylene group, alkenyl group, alkynyl group, heteroalkylene group, cycloalkylene group, heterocylcoalkylene group, arylene group or heteroarylene group, where each of the said groups can be substituted, Q is CR⁴, X is CR⁷ or N, Y is CR⁶ or N, n equals 1, 2 or 3, m equals 1, 2 or 3, R¹ is H, F, Cl, Br, I, OH, NH₂, alkyl group or heteroalkyl group, R is H, F or Cl, R³ is H, alkyl group, alkenyl group, alkynyl group, heteroalkyl group, cycloalkyl group, heterocycloalkyl group, aryl group, heteroaryl group, alkylaryl group or heteroarylalkyl group, where each of the said groups can be substituted with one, two or more halogen atoms or amino groups, R⁴ is hydroxy, a group with formula OPO₃R⁹ ₂ or OSO₃R¹⁰ or a heteroalkyl group, containing at least one OH, NH₂, SO₃R¹⁰, PO₃R⁹ ₂ or COOH group or ester group of natural amino acid or its derivative, where R⁹ groups independently represent H, alkyl, cycloalkyl, aryl or aralkyl, and R¹⁰ is H, alkyl, cycloalkyl, aryl or aralkyl, and further values of R⁵, R⁶, R⁷ and R⁸ are given in the formula of invention. The invention also relates to pharmaceutical compositions with antibacterial activity, containing compounds described above, as well as to use of formula (I) compounds and a pharmaceutical composition for treating bacterial infection.

EFFECT: new compounds are obtained and described, which can be used as antibacterial agents and which are effective against multi-drug resistant bacteria.

18 cl, 32 ex