FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a medicinal formulation with partially sustained-release effect. The pharmaceutical active substance is tramadol that is represented partially in the form of compound formed in situ with water solubility ≤100 mg/ml. Tramadol and acid pharmaceutical active substance and/or accessory substance, or their corresponding water-soluble salts and optionally other accessory substances are mixed, wetted some times and the mixture is processed to the end composition using energy supply.
EFFECT: reduced cost of process, valuable pharmaceutical properties of formulation.
29 cl, 7 tbl, 7 ex
