FIELD: medicine; pharmacology.
SUBSTANCE: provided: combination for the treatment of pain comprising tapentadol or a pharmaceutically acceptable salt thereof and at least one opioid antagonist selected from the group consisting of naloxone and naltrexone and their pharmaceutically acceptable salts and mixtures thereof, wherein tapentadol is in a sustained release form and said antagonist improves the efficacy and / or reduces the side effects of tapentadol, and the appropriate method of treating pain by administering this combination.
EFFECT: technical result is to enhance the analgesic effect of the combination within 12 hours after its administration, while methylnitrexone reduced tapentadol-induced constipation in humans.
7 cl, 17 dwg, 10 tbl, 5 ex
