FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a therapeutic preparation as granule designated for oral administration and adopted for providing immediate and prolonged release of a medicinal agent. Each granule comprises an internal core prepared by extrusion-spheronization method that comprises at least one medicinal agent with the modified release of one or more water-soluble and/or lipid-soluble vitamins, and external layer including at least one medicinal agent with sustained-release of one or more water-soluble vitamins. Composition involves also a coating between internal core and external layer for sustained-release of components wherein indicated coating regulates releasing a medicinal agent from internal core, and a dosed formulation for oral administration also, a method for preparing and granule preparing by this method. Invention provides preparing a vitamin-containing preparation with sustained-release of therapeutic agent.
EFFECT: valuable pharmaceutical properties of composition.
15 cl, 2 ex
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