FIELD: medicine, pharmaceutics.
SUBSTANCE: composition for vaginal application includes granules, obtained from crystalline cleaved starch. The composition also includes a plasticiser and a therapeutic preparation, selected from metronidazole, miconazole nitrate, medroxyprogesterone acetate. The granules can be easily obtained by pressing/spheronisation. The granules are in a form of a vaginal suppository, a tablet or a capsule. Also described is a method of introduction of the vaginal composition to a patient.
EFFECT: granules by the invention possess better distribution and delay in the fornix, middle part of vagina mucosa and near vagina orifice in comparison with a composition, where as a granule excipient used is microcrystalline cellulose and without crystalline cleaved starch.
12 cl, 5 tbl, 2 ex
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