TRICYCLIC BENZODIAZEPINES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHODS FOR HYPERTENSION TREATMENT Russian patent published in 2005 - IPC

FIELD: organic chemistry, madicine.

SUBSTANCE: tricyclic benzodiazepines of formula I as well as their pharmaceutical acceptable salts, pharmaceutical composition containing the same and methods for hypertension treatment are disclosed. In formula A is -C(O)-; Y is CH₂ or CH as olefinic site; X is CH₂ or CH as olefinic site S, O or NR₃ (R₃ is C1-C8-alkyl) with the proviso that when Y is CH, X also is CH; Z is N or CH; R₁ is hydrogen, C1-C8-alkyl, C1-C8-alkoxy or halogen; R₂ is NR₄COAr (R₄ is hydrogen; Ar is phenyl optionally substituted with 1-3 substitutes independently selected from C1-C8-alkyl, halogen, hydroxyl, fluorinated C1-C8-alkylthio and another phenyl optionally substituted with substitute selected from C1-C4-alkyl, halogen, and hydroxyl); R₅ is hydrogen, C1-C4-alkyl, C1-C4-alkoxy, fluorine, chlorine, hydroxyl or di-(C1-C4)-alkylamino.

EFFECT: improved pharmaceutical composition for hypertension treatment.

12 cl, 5 tbl, 52 ex