FIELD: organic chemistry.
SUBSTANCE: method relates to new method for production of 5-chloro-4-[(2-imidazoline-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride of formula I 
. Claimed compound is high effective drug and is used in medicine as myorelaxant of central action. Claimed method includes condensation of N,N-dimethyldichloromethyleneammonium chloride with 5-chloro-4-amino-1,1,3-benzothiadiazole in organic solvent followed by treatment of formed alpha-chloroformamidine of formula R-N=C(Cl)N(CH3)2, wherein R is 5-chloro-2,1,3-benzothiazol-4-yl, with ethylenediamine. Formed intermediate of formula R-N=C(NH-CH2-CH2-NH2)N(CH3)2 is treated with hydrochloric acid, heated in organic solvent and 5-chloro-4-[(2-imidazoline-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride of formula I is isolated.
EFFECT: simplified method for preparation of target compound directly in hydrochloride form.
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 5-BROMO-6-[(2-IMIDAZOLIN-2-YL)AMINO]QUINOXALINE L-TARTRATE | 2005 |
|
RU2285003C1 |
| METHOD OF PREPARING SUBSTITUTED 2-(PHENYLAMINO)-2- IMIDAZOLINES | 1997 |
|
RU2131872C1 |
| METHOD OF SYNTHESIS OF 2-(2,6-DICHLOROPHENYLAMINO)-2- -IMIDAZOLINE HYDROCHLORIDE | 1997 |
|
RU2133247C1 |
| 0 |
|
SU493966A3 | |
| OXIME DERIVATIVE OF CYCLOHEX-2-ENE-1-ON AND METHOD FOR SUPPRESSION OF UNDESIRABLE PLANTS GROWTH | 1988 |
|
RU2009138C1 |
| 0 |
|
SU513626A3 | |
| METHOD FOR PREPARING 5-CHLORO-4-[(2-IMIDAZOLINE-2-YL)AMINO]-2,1,3-BENZOTHIADIZOLE | 2003 |
|
RU2237669C1 |
| PROCESS FOR PRODUCING 2-(2',2',2'-TRIHALOETHYL)-4-HALOCYCLOBUTAN-1-ONES | 0 |
|
SU917695A3 |
| PYRANOBENZOXADIAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1989 |
|
RU2054007C1 |
| PROCESS FOR PREPARING 4-SUBSTITUTED ANTHRACYCLINONES | 1989 |
|
RU2071463C1 |
