FIELD: antibiotics, chemical technology.
SUBSTANCE: azithromycin is prepared by the methylation reaction of 11-aza-10-deoxo-10-dihydroerythromycin in boiling in chlorinated hydrocarbon medium, in the presence of formic acid taken in the amount from 0.1 to 0.2 weight part per one weight part of 11-aza-10-deoxo-10-dihydroerythromycin. Paraform is used as a methylating agent taken in the amount from 0.05 to 0.2 weight part per one part of 11-aza-10-deoxo-10-dihydroerythromycin. Invention provides increasing yield and improved quality of the end product.
EFFECT: improved preparing method.
2 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PREPARING AZITROMICYN AND METHODS FOR PRODUCTION OF INTERMEDIATES | 1996 |
|
RU2144924C1 |
| O-METHYL DERIVATIVES OF AZITHROMYCIN A SHOWING ANTIBACTERIAL ACTIVITY, AZITHROMYCINS AS INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF O-METHYL DERIVATIVES OF AZITHROMYCIN A AND A METHOD OF SYNTHESIS OF O-METHYL DERIVATIVES OF AZITHROMYCIN A | 1991 |
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| METHOD FOR CRYSTALLIZING AZITHROMYCIN DIHYDRATE | 2004 |
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| 10-DIHYDRO-10-DESOXO-11-AZAERYTHRONOLIDE A DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PROCESS FOR PREPARING SAME | 1988 |
|
RU2007398C1 |
| PROCESS FOR PREPARING DERIVATIVES OF 11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCIN A | 0 |
|
SU1093253A3 |
| METHOD OF PREPARING 1-NITROSO-4-METHYLPIPERAZINE | 1993 |
|
RU2095355C1 |
| 0 |
|
SU423294A3 | |
| METHOD OF OBTAINING METAL COMPLEXES OF ERITHRIMYCIN A DERIVATIVES WITH BIVALENT METALS CU, ZN, NI OR CA IN RATIO 2:1, SHOWING BACTERICIDE ACTIVITY | 0 |
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| 0 |
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RU2225413C1 |
