FIELD: antibiotics, chemical technology.
SUBSTANCE: crystallization of azithromycin dihydrate is carried out by alkalization of an aqueous-organic azithromycin salt with the ratio water/solvent = from 1:1 to 3;1 and up to pH value 8-10. Methanol, ethanol, isopropanol, acetonitrile or dioxane can be used as a solvent. Method provides enhancing stability and homogeneity of the end crystalline product.
EFFECT: improved crystallizing method.
1 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING ERYTHROMYCIN OXIME | 2004 |
|
RU2256665C1 |
| METHOD FOR ISOLATING OXACILLIN SODIUM SALT FROM AQUEOUS AND AQUEOUS-ORGANIC MEDIA | 2004 |
|
RU2272041C1 |
| METHOD OF PRODUCTION OF MONOHYDRATE OF TETRAAMMINE COPPER (II) SULFATE | 2003 |
|
RU2251528C1 |
| CRYSTALLINE AZITHROMYCIN L-MALATE MONOHYDRATE AND PHARMACEUTICAL COMPOSITION INCLUDING IT | 2006 |
|
RU2348644C1 |
| METHOD OF AZITHROMYCIN DIHYDROCHLORIDE PREPARING | 1995 |
|
RU2134271C1 |
| AZITHROMYCIN ETHANOLATE, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF | 1999 |
|
RU2240124C2 |
| CLOPIDOGREL PROCESS AND INTERMEDIATE COMPOUNDS THEREFOR | 2005 |
|
RU2357970C1 |
| SYNTHESIS METHOD OF 9-ALLYLCAMPTOTHECIN DERIVATIVES | 2014 |
|
RU2658017C2 |
| NOVEL POLYMORPHS AND SALTS | 2011 |
|
RU2573384C2 |
| LOBAPLATIN CRYSTALS, METHODS OF PRODUCTION AND APPLICATIONS IN PHARMACEUTICALS | 2014 |
|
RU2648990C1 |
