FIELD: chemistry of heterocyclic compounds, chemical technology, pharmacy.
SUBSTANCE: invention relates to a method for preparing 1,2,5-trimethyl-4-phenyl-4-propionyloxypiperidine hydrochloride (promedol) used extensively as an analgetic medicinal agent. Method involves reaction of 1,2,5-trimethylpiperidone-4 with aromatic compound of alkaline or earth-alkaline metal that is carried out at temperature from -10°C to -100°C and wherein 1-1.15 mol of aromatic compound of alkaline or earth-alkaline metal, in particular, phenyllithium or phenylmagnesium bromide is used per 1 mol of 1,2,5-trimethylpiperidone-4 followed by two-fold treatment with propionyl chloride. Invention provides enhancing yield of promedol.
EFFECT: improved preparing method.
5 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING 2,5-DIMETHYL-4-PHENYL-4-PROPIONYL-OXYPIPERIDINE | 0 |
|
SU1165679A1 |
| 1,-(4Ъ-PHENOXYBUTIN-2Ъ-IL)-4-PHENYL-4-OXYPIPERIDINE AS INTERMEDIATE COMBINATION IN SYNTHESIS OF HYDROCHLORIDE(1,4Ъ-PHENOXYBUTYL)-4-PHENYL-4-PROPIONYLOXYPIPERIDINE POSSESSING ANALGETIC ACTIVITY AND HYDROCHLORIDE 1-(4Ъ-PHENOXYBUTYL)-4-PHENYL-4-PROPIONYLOXYPIPERIDINE POSSESSING ANALGETIC ACTIVITY | 0 |
|
SU1233452A1 |
| 1-(3-BUTOXY PROPYL) -4-OXOPIPERIDINE AS INTERMEDIATE COMPOUND IN SYNTHESIS OF 1-(3-BUTOXY PROPYL) -4-PHENYL-4-PROPIONYLOXYPIPERIDINE HYDROCHLORIDE HAVING ANALGESIC ACTIVITY | 1991 |
|
SU1833618A3 |
| O-BENXOYLOXIME1,2,5-TRIMETHYLPIPERYDON-4 HYDROCHLORIDE | 1984 |
|
RU1220298C |
| 1,2,5-TRIMETHYL-1-(TRIMETHYL-ACETOXYMETHYL)-4-PROPIONYLOXY-4-PHENYLPIPERIDINIUM CHLORIDE EXHIBITING PROTRACTED ANALGETIC EFFECT | 0 |
|
SU990759A1 |
| METHOD OF SYNTHESIS OF 1,2,5-TRIMETHYL-4-PIPERIDONE | 1997 |
|
RU2123495C1 |
| METHOD OF OBTAINING 1,3,4-TRISUBSTITUTED 4-ARYLPIPERIDINES OR SALTS THEREOF | 0 |
|
SU629875A3 |
| 4-PHENYLPIPERIDINE DERIVATIVES POSSESSING ANALGETIC ACTIVITY | 0 |
|
SU591466A1 |
| 0 |
|
SU476256A1 | |
| 0 |
|
SU508502A1 |
