FIELD: organic chemistry and technology. SUBSTANCE: method involves an interaction of chlorinated ketone with methylamine an aqueous solution at mole ratio = 1:(2-2.25). A solution of isopropenyl-2-chloropropylketone of the general formula is used as chlorinated ketone in methylene chloride and reaction is carried out at 40-45 C, not above. The use of methylene chloride decreases degree of fire-explosion hazard, ensures to decrease duration of the main reaction by about two-fold and eliminate secondary stages of process including steaming, extraction and drying and decrease consumption coefficients by raw. Synthesized compound is used as semiproduct for synthesis of drug - promedol. EFFECT: improved method of synthesis. 1 tbl, 1 ex
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Authors
Dates
1998-12-20—Published
1997-03-03—Filed