AGENT PROMOTING PRODUCTION/SECRETION OF NEUROTROPHINE COMPRISING AZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of azole of the formula:

wherein R¹ represents (1) halogen atom; (2) nitrogen-containing 5- or 6-membered heterocyclic group comprising from 1 to 4 nitrogen atoms as atoms of ring system in addition to carbon atoms, and group with condensed rings comprising nitrogen-containing 5- or 6-membered heterocyclic group comprising 1-2 nitrogen atoms as atoms of ring system in addition to carbon atoms, and benzene ring wherein nitrogen-containing 5- or 6-membered heterocyclic group and group with condensed rings can comprise optionally from 1 to 3 substituted taken among group consisting of: (i) aliphatic hydrocarbon group comprising from 1 to 15 carbon atoms; (ii) (C₆-C₁₄)-aryl group, and (iii) carboxy-group that can be in form of group of (C₁-C₆)-alkyl ester wherein above indicated substitutes (i)-(iii) can have from 1 to 3 substituted additionally taken among group consisting of: (a) carboxyl group and (b) hydroxy-group; (3) (C₁-C₁₀)-alkylsulfanyl group that can be substituted with hydroxy-group; (4) heteroarylsulfanyl group taken among pyridylsulfanyl, imidazolylsulfanyl and pyrimidinylsulfanyl, or (5) amino-group that can be mono- or di-substituted optionally with substitutes(substitutes) among group consisting of: (i) (C₁-C₁₀)-alkyl group that can be substituted with hydroxy-group, and (ii) (C₇-C₁₀)-aralkyl group; A^b represents aryloxy-group that is substituted with alkyl group and can be substituted with halogen atom, (C₁-C₄)-alkoxy-group, (C₁-C₄)-alkyl group, hydroxy-group or (C₁-C₆)-alkylcarbonyloxy-group additionally; B represents (C₆-C₁₄)-aryl group or thienyl group each of that can has optionally from 1 to 4 substitutes taken among halogen atom, (C₁-C₆)-alkoxy-group and (C₁-C₆)-alkyl group that can has optionally from 1 to 3 halogen atoms; Y represents saturated aliphatic bivalent group with direct or branched chain and having from 1 to 7 carbon atoms, or to its salt. Also, invention relates to a pharmaceutical composition that elicits activity for promoting production/secretion of neurotrophine, and to methods for prophylaxis and treatment based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof used for prophylaxis and treatment of neuropathy.

EFFECT: improved and valuable medicinal properties of agent, improved methods for treatment.

19 cl, 1 dwg, 5 tbl, 122 ex