SOMATOSTATIN AGONISTS Russian patent published in 2005 - IPC

FIELD: organic chemistry, amino acids.

SUBSTANCE: invention proposes agonists of somatostatin of the formula (I): X-A¹-cyclo-(D-Cys-A³-A⁴-Lys-A⁶-A⁷)-A⁸-Y or its pharmaceutically acceptable salt wherein X represents hydrogen atom (H); A¹ represents L-Cpa, L-Phe, L-Trp or L-Nal; A³ represents L-3-Pal or L-4-Pal; A⁴ represents D-Trp; A⁶ represents -NH-(CHR¹)_n-CO- wherein n = 2, 3 or 4; A⁷ represents L- or D-Cys; A⁸ represents D- or L-isomer of amino acid taken among the group consisting of Nal, Phe, Cpa and Trp; Y represents NH₂; R¹ represents hydrogen atom (H), and Cys in A³ is bound by disulfide bong in A wherein this disulfide bond is formed by thiol groups of each Cys residue.

EFFECT: valuable biological properties of compounds.

9 cl, 2 ex