FIELD: organic chemistry of natural compounds, medicine.
SUBSTANCE: invention relates to new taxanes with carbonate substitute at C7 of the general formula (I) given in the invention description wherein R2 means benzoyloxy group; R7 means -COO; R9 means -CO; R10 means -OH; R14 means hydrogen atom (H); X3 means (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C6)-cycloalkyl or 5-membered heteroaromatic group wherein heteroatom is represented by oxygen (O) or sulfur (S) atom; X5 means -COX10, -COOX10 wherein X10 means (C1-C6)-alkyl, (C2-C6)-alkenyl, phenyl or 5-membered heteroaromatic group wherein heteroatom is represented by oxygen (O) or sulfur (S) atom, and Ac means acetyl. Proposed compounds possess an anti-tumor activity.
EFFECT: valuable medicinal properties of compounds.
61 cl, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| C7-ESTER-SUBSTITUTED TAXANES AS ANTI-TUMOR AGENTS | 2001 |
|
RU2265017C2 |
| TAXANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR INHIBITION OF TUMOR GROWTH | 2001 |
|
RU2264400C2 |
| STAUROSPORIN DERIVATIVES USED FOR TREATING ALVEOLAR RHABDOMYOBLASTOMA | 2006 |
|
RU2443421C2 |
| CATALYST SYSTEM | 2003 |
|
RU2326123C2 |
| SUBSTITUTED ANILIDES, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT | 1998 |
|
RU2233269C2 |
| AMIDES OF ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2208608C2 |
| MONOMER DERIVATIVES OF GLYCOPEPTIDE ANTIBIOTIC | 2005 |
|
RU2424248C2 |
| DERIVATIVES SHOWING PPAR-RECEPTOR AGONIST ACTIVITY | 2006 |
|
RU2415846C2 |
| AGENT WHICH PREVENTS PREMATURE OVULATION | 2006 |
|
RU2419435C2 |
| USE OF CARBOCYCLIC AND HETEROCYCLIC ANELLATED DIHYDROPYRIDINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AS BLOCKER OF NONSELECTIVE CHANNEL OF CATIONS IN PROTECTION OF BRAIN AND FOR TREATMENT OF PATIENTS WITH CHRONIC BRONCHIAL ASTHMA | 1991 |
|
RU2149000C1 |
