FIELD: microbiological industry, antibiotics, chemical technology.
SUBSTANCE: invention relates to a method for preparing benzylpenicillin sodium salt possessing an antibacterial, anti-inflammatory effect and relating to group of β-lactams. Method involves passing 31-38% aqueous solution of benzylpenicillin potassium salt through sulfocation-exchange resin KU-2-8 in Na+-form at the rate 2-3 volumes of solution per 1 volume of resin/h at 8-10°C and isolation of ready product. Method provides simplifying the technological process in simultaneous preparing benzylpenicillin sodium salt of high quality.
EFFECT: improved preparing method.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| FUNGUS STRAIN PENICILLIUM CHRYSOGENUM - A PRODUCER OF BENZYLPENICILLIN AND PHENOXYMETHYLPENICILLIN | 1991 |
|
RU2035514C1 |
| METHOD OF PREPARING SODIUM SALT OF BENZYLPENICILLIN | 0 |
|
SU124588A1 |
| METHOD FOR ISOLATION OF ACIDS OF β-LACTAM ANTIBIOTICS | 1996 |
|
RU2107068C1 |
| METHOD OF ISOLATION OF PHENOXYMETHYLPENICILLIN POTASSIUM SALT | 2001 |
|
RU2202554C2 |
| METHOD OF PREPARING THE HIGHLY PURIFIED PHENOXYMETHYLPENICILLIN | 1994 |
|
RU2088585C1 |
| METHOD OF PHENOXYMETHYLPENICILLIN POTASSIUM SALT PREPARATION | 0 |
|
SU1726479A1 |
| METHOD OF PREPARING POTASSIUM SALT OF BENZYLPENICILLIN | 0 |
|
SU131037A1 |
| FUNGAL STRAIN PENICILLIUM CHRYSOGENUM PRODUCING BENZYL PENICILLIN AND PHENOXY METHYL PENICILLIN | 1988 |
|
SU1549075A1 |
| METHOD FOR ISOLATION OF BIOLOGICALLY ACTIVE SUBSTANCES | 1994 |
|
RU2079555C1 |
| METHOD OF PRODUCING COMPACTIN | 2013 |
|
RU2585234C2 |
