FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to the improved method for preparing trisamine representing tri-(hydroxymethyl)-aminomethane that possesses antacide activity with systemic effect and can be used, in particular, for correction of acid-alkaline equilibrium. Method involves reduction reaction of nitro-group with hydrogen in tri-(hydroxymethyl)-nitromethane (nitrotris) used as a solution in an organic solvent (methanol, ethanol, acetonitrile) at temperature 5-20°C in the presence of palladium catalyst applied on carbon in the concentration of palladium from 1 to 5% of the parent substance mass, and under pressure 1-2 kgf/cm2. The end product is isolated by separation of solution from catalyst by filtration followed by evaporation of solution under vacuum at temperature 50°C, not above, cooling and filtration. Method provides enhancing the technological effectiveness of the process, in particular, due to reducing temperature and pressure values.
EFFECT: improved preparing method.
2 cl, 1 ex
