FIELD: peptides, pharmacy.
SUBSTANCE: invention relates to a new method for preparing a pharmaceutical composition for the parenteral administration in mammals that comprises salt of difficulty soluble peptides. Method involves treatment of the parent readily soluble acid-additive salt of the basic peptide of LHRH antagonist in the presence of suitable diluting agent with the mixed ion-exchange resin or mixture of acid and basic ion-exchange resins to form free basic peptide. Then ion-exchange resin is removed and free basic peptide is treated with inorganic or organic acid to form the final product, required acid-additive peptide salt followed by addition of suitable pharmaceutical vehicles and/or filling agents and removal of a diluting agent.
EFFECT: improved preparing method.
5 cl, 1 dwg, 1 ex
| Title |
Year |
Author |
Number |
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2000 |
- Bauehr Khorst
- Damm Mikhel'
- Deger Vol'Fgang
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|
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|
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1994 |
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- Klokkers-Betke Karin
- Rejssman Tomas
- Khil'Gard Peter
|
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2001 |
- Bekers Tomas
- Bernd Mikhaehl'
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|
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2002 |
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|
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|
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| PHARMACEUTICAL GEL COMPOSITION FOR TREATMENT OF DISEASES, METHOD FOR OBTAINING SAME AND RESPECTIVE KIT |
2003 |
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|
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|
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1998 |
- Deger Vol'Fgang
- Losse Gjunter
- Murgas Sandra
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- Ehngel' Jurgen
|
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