METHOD FOR PREVENTING HYDROPHOBIC PEPTIDE GEL FORMATION, COMPOSITION OF HYDROPHOBIC PEPTIDE (VARIANTS) AND METHOD FOR ITS PREPARING (VARIANTS) Russian patent published in 2007 - IPC A61K38/09 A61K47/24 

Abstract RU 2311195 C2

FIELD: medicine, pharmaceutical chemistry.

SUBSTANCE: invention relates to a method for preventing formation of hydrophobic peptides gel, namely, "Teverelix". Method involves its contacting with counter-ion in the amount and in the molar ratio providing preparing liquid milk-like, microcrystalline aqueous suspension of peptide being without the gel formation. Also, invention relates to liquid, milk-like, microcrystalline aqueous suspension of "Teverelix" and counter-ion in water wherein peptide and counter-ions present in amounts and molar ratio providing formation of suspension without formation of gel in stirring. Invention provides enhancing stability of peptide.

EFFECT: improved preventing and preparing method.

35 cl, 8 ex

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RU 2 311 195 C2

Authors

Butin'On Fransua

Degengi Romano

Dates

2007-11-27Published

2002-08-27Filed