AMIDE DERIVATIVES OF CARBOXYLIC ACID, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF Russian patent published in 2006 - IPC C07D498/04 C07D487/04 C07D401/06 A61K31/404 A61K31/405 A61K31/4523 A61K31/4184 A61K31/424 A61P25/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new amide derivatives of carboxylic acid that are antagonists of NMDA receptors of the formula (I): , wherein one radical among R¹, R², R³ and R⁴ represents -OH or NH₂-group and others are hydrogen atoms; or two adjacent groups R¹, R², R³ and R⁴ in this case in common with one or more similar or different additional heteroatoms and -CH= and/or -CH₂-groups form 5-6-membvered homo- or heterocyclic ring but preferably pyrrole, pyrazole, imidazole, oxazole, oxooxazolidine or 3-oxo-1,4-oxazine ring; two other groups among R¹, R², R³ and R⁴ radicals represent hydrogen atoms; R⁵ and R⁶ in common with nitrogen atom between them form saturated or unsaturated 4-6-membered heterocyclic ring that is substituted with phenoxy-, phenyl-[(C₁-C₄)-alkoxy]-, phenoxy-[(C₁-C₄)-alkyl]-, benzoyl-group optionally substituted in aromatic ring with one or more halogen atoms, (C₁-C₄)-alkyl or (C₁-C₄)-alkoxy-group; X and Y mean independently oxygen, nitrogen atom or group -CH=, and to their salts formed with acids and bases. Also, invention relates to a method for preparing compounds of the formula (I) and pharmaceutical compositions showing activity as selective antagonists of NR2B receptor based on these compounds. Invention provides preparing new compounds and pharmaceutical compositions based on thereof for aims in treatment of the following diseases: chronic neurodegenerative diseases, chronic painful states, bacterial and viral infections.

EFFECT: improved preparing method, valuable medicinal properties of compounds and compositions.

11 cl, 2 tbl, 27 ex