BENZYLPIPERIDINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION AND METHOD OF PREPARATION THEREOF Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are new benzylpiperidine derivatives of formula I: wherein R¹ is H or Hal; R² is unsubstituted or substituted Hal in aromatic ring, benzyl group in position 2,3 or 4 of piperidine ring, provided that R² is other than 4- benzyl when X is -CO; Y and Z are CH₂, and R¹ is H; R³ is H or A, X is CO, Y is CO, Y is CH₂, NH or -0- is CH₂ or bond; A is C_1-6 alkyl, B is O, H+OH, Hal is F, Cl, Ar or J, and also salts thereof. Compounds of formula I have inhibiting activity with respect to binding sigma receptors and are useful for treating neurodegenerative diseases. EFFECT: improved properties of the title compounds. 6 cl, 11 ex, 1 tbl