SUBSTANCE POSSESSING ANTIOXIDANT, GEROPROTECTING AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR ITS PREPARING Russian patent published in 2006 - IPC C07D213/65 A61K31/44 A61P9/10 A61P39/06

Abstract RU 2276138 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to pharmaceutically acceptable salts of 2,4,6-trimethyl-2-hydroxypyridine with lower dicarboxylic acids of the general formulae (1-a-d): possessing an antioxidant activity wherein X means a simple bond (compound 1a), oxalate, C₈H₁₁NO x C₂H₂O₄; X means -CH₂ (compound 1b), malonate, C₈H₁₁NO x C₃H₄O₄; X means -CH₂-CH₂(compound 1c), succinate, C₈H₁₁NO x C₄H₆O₄); X means the group -CH₂CH(OH) (compound 1d), malate, C₈H₁₁NO x C₄H₆O₅. Also, invention relates to a pharmaceutical composition of salt of the formula (1c) possessing geroprotecting and anti-ischemic activities, and to a method for preparing these salts.

EFFECT: improved preparing method, valuable medicinal properties of substances and pharmaceutical composition.

3 cl, 5 tbl, 6 ex

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RU 2 276 138 C2

Authors

Dates

2006-05-10—Published

2004-05-12—Filed