FIELD: organic chemistry, drugs.
SUBSTANCE: invention relates to complex of general formula (X)n-Y, wherein X are identical or different and represent folic acid, folinic acid, dihydrofolic acid, tetrahydrofolic acid, tetrahyldopterine, pteroyl-polyglutamic acid, 2-deaminohydroxyfolic acid, 1-denitrofolic acid, 3-denitrofolic acid, 8-denitrofolic acid; Y represents polysaccharide different from arabinogalactane, selected from group containing glucanes, dextranes, polysaccharoses, fructosanes, heteropolysaccharides, homo- or heteropolysaccharide sulfates, ginseng pectin polysaccharide and other pectin polysaccharides, gumghatti, alginate, etc; or Y is selected from polyethylene oxide, methoxypolyethylene glycol and hydrophilic alcohol polymers; n >=1. Said complex permeates into in cell via pathway involving folic acid receptor on cell membrane. Complex of present invention is useful in production of pharmaceutical agents having antitumor activity.
EFFECT: new intermediates for antitumor agent production.
10 cl, 7 ex, 11 dwg, 2 tbl
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