HUMAN ANTIBODIES TO IL-β1 Russian patent published in 2006 - IPC C07K16/24 C12N15/25 C12N15/63 C12P21/00 

FIELD: immunology, biology.

SUBSTANCE: invention relates to variants of IL-1β-binding molecule having common functionally active sites (CDR sites) and may bind human IL-1β. Said molecules have neutralizing activity IC₅₀ of approximately 50 pM and binding constant K_D of approximately 30 pM. Amino acid sequence is described in description of present invention. Variants of DNA constructs encoding of heavy chain and light chain of IL-1β-binding molecule are disclosed. Expression vectors carrying at least one abovementioned nuclear acid and method for production of IL-1β-binding molecules by using the same also are described.

EFFECT: IL-1β-binding molecules against human IL-1β with high neutralizing activity and binding constant useful in suppression of HAMA response.

10 cl, 1 dwg, 3 tbl, 4 ex