AGONISTS OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR Russian patent published in 2006 - IPC C07K14/575 

FIELD: medicine, peptides.

SUBSTANCE: invention relates to biologically active compounds representing isolated derivatives of corticotropin-releasing factor. Invention presents non-native peptide of the formula: I-V-L-S-L-D-V-P-I-G-L-L-Q-I-L-L-E-Q-X₁₉-K-X₂₁-X₂₂-X₂₃-X₂₄-X₂₅-X₂₆-Q-A-T-T-N-A-R-I-L-A-R-V (SEQ ID NO: 531) wherein (a) X₁₉ is chosen from the group consisting of D and E; (b) X₂₁ is chosen from the group consisting of A and Q; (c) X₂₂ is chosen from the group consisting of R, E and K; (d) X₂₃ is chosen from the group consisting of A, K and N; (e) X₂₄ is chosen from the group consisting of A, E and L; (f) X₂₅ is chosen from the group consisting of R and K; (g) X₂₆ is chosen from the group consisting of E and Q. Isolated derivatives of corticotropin-releasing factor and nucleic acids encoding thereof are effective agents used in treatment of disorders modulated by corticotropin-releasing factor-2, such as muscular dystrophy.

EFFECT: valuable medicinal properties of agonists.