FIELD: biotechnology, medicine, pharmacy.
SUBSTANCE: invention proposes peptides as agonists of corticotropin-releasing factor CRF2R prepared by solid-phase synthesis. Synthesized agonists of CRF2R are used as components of pharmaceutical composition used in prophylaxis or treatment of diseases modulated by CRF2R. Proposed invention provides enhancing effectiveness of therapeutic effect and avoiding by-side responses in treatment of disorders modulated by CRF2R. Invention can be used in synthesis of novel peptides possessing activity of agonists of corticotropin-releasing factor-2 (CRF2R).
EFFECT: improved method of synthesis, valuable medicinal properties of agonists.
3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGONISTS OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR | 2003 |
|
RU2286995C2 |
| CORTICOTROPIN-RELEASING FACTOR RECEPTOR AGONISTS AND USES THEREOF | 2003 |
|
RU2305110C2 |
| METHODS FOR IDENTIFYING COMPOUNDS USED FOR REGULATION OF MUSCLE MASS OR FUNCTION WITH APPLYING RECEPTORS OF CORTICOTROPIN RELEASING-FACTOR | 2002 |
|
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| UROCORTIN-III, ITS ANALOG (VARIANTS) AND PHARMACEUTICAL COMPOSITION | 2002 |
|
RU2305109C2 |
| UROCORTIN PROTEINS AND THEIR USING | 2001 |
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RU2278871C2 |
| COMPOSITIONS AND METHODS RELATED TO SOLUBLE G-PROTEIN CONJUGATE RECEPTORS (SGPCR) | 2006 |
|
RU2423378C2 |
| DOUBLE TARGETING OF NUCLEOTIDE SEQUENCES MIR-208 AND MIR 499 IN TREATING CARDIAC DISEASES | 2010 |
|
RU2515926C2 |
| IMPROVED ANTIBODIES GDF-8 ANTAGONISTS AND THEIR USE | 2013 |
|
RU2630634C2 |
| THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS | 2013 |
|
RU2655811C2 |
| REGULATION OF METABOLISM USING MIR-378 | 2011 |
|
RU2585491C2 |
