METHOD FOR PREDICTING THE RESULTS OF TREATING PATIENTS WITH CHRONIC HEPATITIS C WITH INTERFERON-ALPHA PREPARATIONS Russian patent published in 2006 - IPC G01N33/68 

FIELD: medicine, gastroenterology.

SUBSTANCE: one should detect the synthesis of IFN-γ and IL-4 with mononuclears of peripheral blood in vitro before and 4.5 h after introducing the first dosage of interferon-α preparation. At detecting more that 2-fold increase of the synthesis of IFN-γ and the ratio of IFN-γ/IL-4 synthesis after the first introduction of interferon-α preparation for the patients with CVH C it is possible to predict the development of virological response in the course of 24-wk interferonotherapy. In case of increased synthesis of IFN-γ and the ratio of IFN-γ/IL-4 synthesis after the first introduction of interferon-α being less than 2-fold - the development of virological response should not be expected. Application of the present innovation enables to predict the results of therapy in shorter terms after the first introduction of interferon-α preparation.

EFFECT: higher accuracy of prediction.

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