METHOD FOR PREDICTING EFFICIENCY OF INTERFERONOTHERAPY AT CHRONIC HEPATITIS B Russian patent published in 2006 - IPC G01N33/68 

FIELD: medicine, gastroenterology.

SUBSTANCE: one should detect TNF-α content in blood serum and IFN-γ synthesis by mononuclear cells in vitro before and 4.5 h after the first injection of interferon-preparation for a patient. At detecting TNF-α content in blood serum before injection not exceeding 59.31 pg/ml, and at the increase of TNF-α level after the first injection of interferon- being above 46.1 % and IFN-γ synthesis being above 70.25% against initial data one should predict high efficiency of interferonotherapy in the course of a 6-mo-long interferonotherapy. At TNF-α content in blood serum being above 74.51 pg/ml and increased TNF-α values not more than 24.9%, and IFN-γ - not more than 70% or their decrease after the first injection of interferon- it is possible to predict the absence of virological response, that is insufficient efficiency of interferonotherapy. Application of the method suggested enables to predict the results of interferonotherapy in case of chronic viral hepatitis B just after the first injection of interferon- preparation.

EFFECT: higher efficiency of prediction.

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