FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel compounds represented by he general formula (I) and their salts possessing properties of VLA-4 inhibitors, to a medicinal agent based on thereof and their using for preparing a medicinal agent used in treatment of diseases caused by the cellular adhesion. In compound of the formula (I) W represents the group of the following formula: W1-A1-W2- (i) or W3-A1-W4 (ii); R represents -CH2-; M represents the group of the following formula (iii): or the formula (iv): . Values of substitutes W1, W2, W3, W4, A1, A, A3, Q, Q, R10, R11, R12, R13, R14, R15, R16, R16a, R17, Y, Y3, Z and Z Z1 are given in the invention claim.
EFFECT: valuable medicinal properties of inhibitors.
21 cl, 3 tbl, 173 ex
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Authors
Dates
2006-12-27—Published
2001-12-28—Filed