VLA-4 INHIBITORS Russian patent published in 2006 - IPC C07D413/06 C07D413/10 C07D413/12 C07D413/14 C07D403/10 C07D403/12 C07D403/14 C07D263/58 C07D417/12 C07D417/10 A61K31/423 A61K31/437 A61K31/404 A61K31/5415 A61K31/496 A61P29/00 A61P37/06 A61P35/04 A61P11/06 A61P3/10 A61P19/02 A61P17/06 A61P1/04 A61P25/28 

Abstract RU 2290403 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds represented by he general formula (I) and their salts possessing properties of VLA-4 inhibitors, to a medicinal agent based on thereof and their using for preparing a medicinal agent used in treatment of diseases caused by the cellular adhesion. In compound of the formula (I) W represents the group of the following formula: W1-A1-W2- (i) or W3-A1-W4 (ii); R represents -CH2-; M represents the group of the following formula (iii): or the formula (iv): . Values of substitutes W1, W2, W3, W4, A1, A, A3, Q, Q, R10, R11, R12, R13, R14, R15, R16, R16a, R17, Y, Y3, Z and Z Z1 are given in the invention claim.

EFFECT: valuable medicinal properties of inhibitors.

21 cl, 3 tbl, 173 ex

Similar patents RU2290403C2

Title Year Author Number
DIPEPTIDYL PEPTIDASE-IV INHIBITORS 2010
  • Balasubramanian Gopalan
  • Sakamuri Sukumar
  • Singkh Gadzhendra
  • Dkharmalingam Sivanesan
  • Pooppadi Ksavier Franklin
  • Narajanan Shridkhar
  • Mookkan Dzhejamurugan
  • Balasubramanian Dzheganatkha Sivakumar
  • Radzhalingam Agneesvari
  • Kulatkhingal Dzhajanarajan
RU2574410C2
FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS 2014
  • Bifalko Nil
  • Dipetro Lusian V.
  • Khodaus Brajan L.
  • Miduturu Chandrasekkhar V.
RU2704112C2
CYCLOALKENYLARYLIC DERIVATIVES FOR INHIBITING TRANSPORT PROTEIN CHOLESTERIN ESTERS 2012
  • Li So Khi
  • O Chun Tek
  • Li Che Kvan
  • Li Che Von
  • Pe Soyal
  • Kha Nina
  • Li Sera
RU2597266C2
PHENICOL ANTIBACTERIAL AGENTS 2013
  • Curtis Michael
  • Duclos Brian A.
  • Ewin Richard A.
  • Johnson Paul D.
  • Johnson Timothy A.
  • Vairagoundar Rajendran
  • Billen Denis
  • Goodwin Richard M.
  • Haber-Stuk Andrea K.
  • Kyne Graham M.
  • Sheehan Susan M.K.
RU2593204C2
BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED DERIVATIVES OF CYCLOHEXENE AS CETP INHIBITORS 2014
  • Li Dzae Kvang
  • Okh Dzun Taek
  • Li Dzae Von
  • Li Seo Khi
  • Kim Il-Khiang
  • Li Dzae Joung
  • Bae Su Jeal
  • Li Se Ra
  • Kim Yun Tae
RU2627361C2
SUBSTITUTED TRICYCLIC COMPOUNDS AND METHOD OF APPLICATION 2016
  • Altenbach, Robert J.
  • Bogdan, Andrew
  • Cowart, Marlon D.
  • Esmieu, William Ramesh
  • Gfesser, Gregory A.
  • Greszler, Stephen N.
  • Koenig, John R.
  • Kym, Philip R.
  • Liu, Bo
  • Malagu, Karine Fabienne
  • Patel, Sachin V.
  • Scanio, Marc J.
  • Searle, Xenia B.
  • Voight, Eric
  • Wang, Xueqing
  • Yeung, Ming C.
RU2744766C2
CONDENSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE 2007
  • Takakhasi Khisasi
  • Komorija Satosi
  • Kitamura Takakhiro
  • Odagiri Takasi
  • Inagaki Khiroaki
  • Tsuda Tosifumi
  • Nakajama Kijosi
  • Takemura Makoto
  • Josida Keniti
  • Mijauti Rie
  • Nagamoti Masatosi
RU2443698C2
RMT5 INHIBITORS 2019
  • Mashasek, Mishell
  • Vitter, Devid
  • Zhibo, Krejg
  • Khuan, Chunkhoj
  • Kavamura, Sukhei
  • Sloman, Devid, L.
  • Silipkhaivankh, Pkhieng
  • Kiros, Rajan
  • Van, Myurrej
  • Shnajder, Sebastyan
  • Jeung, Charlz, S.
  • Rojtershan, Majkl, Kh.
  • Khenderson, Timoti, Dzh.
  • Paparen, Zhan-Loran
  • Raali, Usin
  • Khyuz, Dzhonatan, M., E.
  • Sanyal, Sulagna
  • Je, Jingchun
  • Kandito, Devid, A.
  • Fajer, Patrik, S.
  • Silverman, Stiven, M.
RU2814198C2
SUBSTITUTED CARBONUCLEOSIDES DERIVATIVES USED AS ANTICANCER AGENTS 2017
  • Kumpf, Robert Arnold
  • Mcalpine, Indrawan James
  • Mctigue, Michele Ann
  • Patman, Ryan
  • Rui, Eugene Yuanjin
  • Tatlock, John Howard
  • Tran-Dube, Michelle Bich
  • Wythes, Martin James
RU2712944C1
NOVEL PHENYL PYRROLE DERIVATIVE 2009
  • Furukava Akikhiro
  • Fukuzaki Takekhiro
  • Onisi Jukari
  • Kobajasi Khideki
  • Khonda Takesi
  • Matsui Jumi
  • Konisi Masakhiro
  • Ueda Kendziro
  • Matsufudzi Tetsujosi
RU2470917C2

RU 2 290 403 C2

Authors

Nakajama Atsusi

Matinaga Nobuo

Joneda Josijuki

Sugimoto Juiti

Tiba Dzun

Vatanabe Tosijuki

Ijmura Sin

Dates

2006-12-27Published

2001-12-28Filed