FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS Russian patent published in 2019 - IPC C07D405/12 A61K31/517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula I and a compound of formula II or a pharmaceutically acceptable salt thereof, which have the properties of a FGFR-4 inhibitor. In compound of formula I

(I)

(II)

head part is , where each of R^a, R^b and R^c is independently selected from H, C_1-4 alkyl, C_1-4 cycloalkyl or cyano; ring A is tetrahydrofuranyl or tetrahydropyranyl; each of R¹ and R² is independently selected from halogen, cyano, C_1-6 alkoxy, hydroxy, oxo, amino, amido and C_1-6 alkyl, where each of C_1-6 alkoxy and C_1-6 alkyl is independently substituted with 0-5 cases of R⁴; R³ is halogen; each R⁴ is independently selected from C_1-6 alkyl, C_1-6 alkoxy, halogen, hydroxy, oxo, amino and cyano; m is 0–3; n is 0–4; and p is equal to 0–2.

EFFECT: compounds can be used in treating a disease or condition mediated by FGFR-4, for example, hepatocellular carcinoma or hyperlipidemia.

21 cl, 2 dwg, 3 tbl, 92 ex