METHOD FOR DIAGNOSING HEPATITIS TRANSIT INTO CHRONIC STAGE Russian patent published in 2007 - IPC G01N33/68 

FIELD: medicine.

SUBSTANCE: method involves determining collagenase, collagenase inhibitor, protease inhibitor activity, free oxyproline and protein-bound oxyproline content. Collagenase activity increasing to 2.2±0.2 mcmole/l*h, protease inhibitor activity falling to 19.2±0.5 IU/ml and lower, collagenase inhibitor content falling to 2.1±0.2 IU/ml and lower, free oxyproline content growing to 1.2±0.02 IU/ml and protein-bound oxyproline content growing to 11.7±0.7 IU/ml, I stage of chronic transition is to be diagnosed. Collagenase activity increasing to 3.52±10.06 mcmole/l*h, collagenase inhibitor activity and protease inhibitor activity and free oxyproline content remaining the same, II stage of chronic transition is to be diagnosed. Collagenase activity increasing to 3.5±0.06 mcmole/l*h, protease inhibitor activity falling to 10.6±0.1 IU/ml and free oxyproline content growing to 1.524±0.06 IU/ml, III stage of chronic transition is to be diagnosed. Collagenase activity increasing to 4.06±0.02 mcmole/l*h, protease inhibitor activity falling to 9.0±0.28 IU/ml and lower, collagenase inhibitor content falling to 1.4±0.1 IU/ml, and protein-bound oxyproline content growing to 12.75±0.1 IU/ml, IV stage of chronic transition is to be diagnosed.

EFFECT: high accuracy of prognosis.

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