PALLADIUM COMPLEXES WITH HETEROCYCLIC LIGANDS Russian patent published in 2007 - IPC C07F15/00 C07D211/76 C07D241/08 C07D265/32 C07D295/10 A61K31/4965 A61K31/5375 A61P35/00 

Abstract RU 2291872 C2

FIELD: chemistry of metalloorganic compounds, medicine, oncology.

SUBSTANCE: invention relates to novel chemical compounds, namely, to complexes of palladium with heterocyclic ligands of the general formula (I): wherein R1 means-NH, oxygen atom (O), -CH2; R2 means two hydrogen atoms (2H), O; R3 means hydrogen atom H, CH3, CH2-CH2-NH2,-(CO)-CH3; X means chlorine (Cl), bromine (Br) atom; n = 1; m = 1 if R1 means -NH, O; R2 means 2H; R3 means H, CH3, CH2-CH2-NH2, -(CO)-CH3; n = 2; m = 1 if R1 means O, -CH2; R2 means O, 2H; R3 means H, CH3, -(CO)-CH3; n = 2; m = 3 if R1 means -NH; R2 means 2H; R3 means CH2-CH2-NH2 eliciting pharmacological, in particular, anti-tumor activity. Proposed compounds possess high activity and characterized by reduced toxicity as compared with anti-tumor preparations with platinum complexes.

EFFECT: valuable medicinal properties of complexes.

4 cl, 2 tbl, 10 ex

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RU 2 291 872 C2

Authors

Efimenko Inehssa Aleksandrovna

Ivanova Nina Aleksandrovna

Lokshin Boris Veniaminovich

Dates

2007-01-20Published

2002-11-12Filed