MICROBALLS CONTAINING THE DERIVATIVE OF PLEUROMUTILINE Russian patent published in 2007 - IPC B01J13/02 B01J13/12 A61K9/16 A61K31/22 A23K1/00 A23K1/17 A61P31/04 

FIELD: cattle breeding; methods of the fodder production.

SUBSTANCE: the invention is pertaining to microballs containing the derivative of pleuromutiline and the method of their production and also to production of the fodder granules containing the microballs and to the method of their production. The microballs have the average size from 1 micron up to 5000 microns and represent the polymeric matrix particles, where the polymeric compound is selected from the shellac, the polymeric compound on the basis of cellulose, the acrylic acid or the methacrylic acid, the maleic anhydride, polyvinyl pyrrolidone or polyvinyl alcohol, and which is highly dispersed in the solid or liquid form with the derivative of pleuromutiline of formula 1 or its physiologically tolerable acid-additive salts and quarternary ammonium salts: , where R₁ means vinyl, between 1 and 2 carbonic atoms there is a single bond, and Ra and Rb mean each separately from each other hydrogenen or halogen, and Т represents -CH₂-S-(CH₂)_K-N_{(R5)(R6), where "k" means the integer from 2 up to 5; R5 andR6 mean each separately from each other C1-C6-alkyl or Т represents -CH2-S-C(CH3)2-CH2-NH-C(O)-CH(NH2)-CH(CH3)2. The method of preparation of the microballs includes production the polymer solution selected from the shellac, the polymetric compound on the basis of cellulose, the acrylic acid or methacrylic acid, the maleic anhydride, polyvinyl pyrrolidone or polyvinyl alcohol, by dissolution of the shellac, the polymetric compound in the organic solvent, having the low affinity to the paraffinic oil or the organosilicic oil and with the dielectric constant from 10 up to 40, with addition of the water. Then the produced solution is introduced at intermixing with the derivative of the pleuromutiline and receive the first organic phase, which is not admixed with the paraffinic oil or the organosilicic oil. The first organic phase introduce at the intense intermixing into the second phase consisting of the paraffinic oil or the organosilicic oil, and prolong intermixing of the produced mixture until the microballs are formed at evaporation or the solvent removal. The microballs are separated, flushed and dried. The fodder granules for the livestock includes the effective number of the indicated above microballs, the milled dry fodder on the vegetable or animal base with or without the additives, such as proteins, vitamins and minerals. The method of preparation of the fodder granules includes the careful intermixing of the microballs with the organic, ground and homogenized components of the fodder. Then they add the water or the steam in the mixture in the amount from 5 up to 10 % of the total mass, press the mixture in the fodder rods at the heightened temperatures from 60 up to 80°С, and divide the rods into the fodder granules. The invention ensures stabilization of the pleuromutiline, which stays undamaged at the granules preparation and is kept safe for the rather long duration of storage.}

EFFECT: the invention ensures stabilization of the pleuromutiline, which stays undamaged at the granules preparation and is kept safe for rather long duration of storage.

6 cl, 3 tbl, 3 ex